Morphologic Change and Hearing Recovery After Intratympanic Application of Insulin-Like Growth Factor-1 in Guinea Pig
نویسندگان
چکیده
Materials and Methods: The coadministration of kanamycin and ethacrynic acid was used to deafen the guinea pigs. An absorbable gelatin sponge immersed in recombinant human insulin-like growth factor-1 (rhIGF-1) was placed on the round window membrane of the experimental ear while a sponge containing saline was applied to control ear. Hearing function was assessed by auditory brain stem responses (ABRs). The temporal bones were collected for analyzing histology of hair cells in the organ of Corti.
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